Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the school announced Thursday, describing it as the largest single gift to a U.

Knight is one of America’s most generous philanthropists, according to Forbes data, donating billions of dollars to educational institutions throughout his life.

Nike founder Phil Knight and his wife, Penny, are giving $2 billion to a cancer institute at University of Oregon that bears their name, the largest ever donation to a US college or academic health institution,