The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both sides of the DNA helix are cut at once. Healthy cells can normally fix ...

The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the integrity of this vast store of information. They constantly untangle ...

Proteins PIF1 and PCNA gather at sites of DNA damage in SETX-deficient cells, indicating activation of the BIR repair system. LA JOLLA, CA—The DNA inside our cells is constantly being damaged, and one ...

Researchers at the University of Bath have discovered how DNA damage caused by a faulty DNA protection and repair system can lead to neurodegenerative disorders such as motor neuron disease (MND).

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

A cell's ability to repair its damaged DNA is one of the most fundamental processes in biology, helping protect us from diseases like cancer. Over the years, researchers have unraveled many of the ...

New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...

When a wound does not heal properly, it leaves a scar. Similarly, mutations—which are permanent changes to genetic code—are often the result of damaged DNA that has not been properly repaired.

Learn more about a new experimental procedure that uses cancer cells’ DNA repair system against itself to make drug-resistant tumors treatable again. Cancer’s ability to adapt is one of its most ...