An AI-identified lipid called P1 delivered mRNA 14.8 times more efficiently than the clinically approved lipid ALC-0315. Lipid P1's unique three-dimensional conformation allows it to bind ...

Super-resolution imaging and mathematical modelling show that clathrin-mediated endocytosis sorts lipids only weakly, with ...

Therapeutics that use mRNA—like some of the COVID-19 vaccines—have enormous potential for the prevention and treatment of many diseases. These therapeutics work by shuttling mRNA "instructions" into ...

Biological processes that govern our lives are many, intertwined, and often difficult to understand. They involve countless interactions happening at once—molecules recognizing each other, signals ...

Lawrence Livermore National Laboratory researchers and a multi-institutional team of scientists have developed a highly detailed, machine learning-backed multiscale model revealing the importance of ...

Non-laboratory-based risk factors and lipids measured in adolescence independently predicted adult cardiovascular events, according to data from seven longitudinal cohort studies. In a multivariable ...