Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered that SARS-CoV-2, the virus that causes ...

This article explores how challenges such as sequence optimization, immune activation and off-target effects are being ...

A study from the University of Maryland, Baltimore County (UMBC), published in Nature Communications, reveals how ...

A new study has explored the RNA-binding mechanisms of the antiviral protein TRIM25. TRIM25 (green, left) finds its way to the same locations in the cell where a virus (red, middle) replicates. The ...

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and ...

Researchers demonstrated how amino acids could spontaneously attach to RNA under early Earth-like conditions using thioesters, providing a long-sought clue to the origins of protein synthesis. This ...

Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, ...

The genetic code is the recipe for life, and provides the instructions for how to make proteins, generally using just 20 amino acids. But certain groups of microbes have an expanded genetic code, in ...

A study by the Federal University of São Paulo describes how SARS-CoV-2 interacts with the RNA of infected lung cells in an unprecedented way. The results may guide the search for new treatments and ...

The innate immune system is the body's first line of defence against pathogens like bacteria or viruses. TRIM25 is a protein that is important in the innate immune response against RNA viruses, such ...