Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...

Structural biology is used to understand the three-dimensional shape of biological molecules and how their shape enables them to function both inside and outside of cells. Furthermore, the ...

A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.

Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Cryo-electron microscopy (cryo-EM) has revolutionalized our understanding of the intricate molecular machinery that governs life. It has elucidated the three-dimensional (3D) structure of biological ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...

Researchers use cryo-EM and optical tweezers to investigate how an antiviral interacts with the herpes simplex virus.

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...