The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...
Rosalind Franklin “was an experimental perfectionist," says crystallographer Elspeth Garman. Franklin: Universal History ...
A record player-like microscope and computer simulations solve a longtime mystery, showing that metal ions bridge DNA strands that would normally repel.
Metal ions bridging the grooves of two DNA helices explain how they lock together, the first direct look at the DNA zipper ...
If you could peer inside a cell's nucleus, you would find DNA tightly packed into a remarkably small space. But that arrangement presents a puzzle: DNA molecules carry the same negative electrical ...
To develop gene therapy tools based on CRISPR-associated transposons (CASTs), it is essential to define how transposon ends are recognized and paired during transposition. Transposon 7 (Tn7)–like ...
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