Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the school announced Thursday, describing it as the largest single gift to a U.

Oregon Health & Science University said the couple’s donation would be the largest single gift to a higher-learning institution in the United States.

The Knight Foundation said the gift that will be used to shift the scientific approach to cancer treatment, research and patient care outcomes.